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Wnt/Wingless signaling in Drosophila.

TitleWnt/Wingless signaling in Drosophila.
Publication TypeJournal Article
Year of Publication2012
AuthorsSwarup S, Verheyen EM
JournalCold Spring Harbor perspectives in biology
Date Published2012 Jun
KeywordsAnimals, Drosophila, Drosophila Proteins, Models, Theoretical, Signal Transduction, Wnt Proteins, Wnt1 Protein

The Wingless (Wg) pathway represents one of the best-characterized intercellular signaling networks. Studies performed in Drosophila over the last 30 years have contributed to our understanding of the role of Wg signaling in the regulation of tissue growth, polarity, and patterning. These studies have revealed mechanisms conserved in the vertebrate Wnt pathways and illustrate the elegance of using the Drosophila model to understand evolutionarily conserved modes of gene regulation. In this article, we describe the function of Wg signaling in patterning the Drosophila embryonic epidermis and wing imaginal disc. As well, we present an overview of the establishment of the Wg morphogen gradient and discuss the differential modes of Wg-regulated gene expression.

Alternate JournalCold Spring Harb Perspect Biol

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