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Guidance of cell migration by the Drosophila PDGF/VEGF receptor.

TitleGuidance of cell migration by the Drosophila PDGF/VEGF receptor.
Publication TypeJournal Article
Year of Publication2001
AuthorsDuchek P, Somogyi K, Jékely G, Beccari S, Rørth P
Date Published2001 Oct 5
KeywordsActins, Amino Acid Sequence, Animals, Cell Movement, Cytoskeletal Proteins, Cytoskeleton, Drosophila melanogaster, Drosophila Proteins, Egg Proteins, Female, Humans, Immunoblotting, Insect Proteins, Ligands, Microscopy, Fluorescence, Molecular Sequence Data, Oocytes, Oogenesis, Ovary, rac GTP-Binding Proteins, Receptor Protein-Tyrosine Kinases, Receptor, Epidermal Growth Factor, Receptors, Growth Factor, Receptors, Platelet-Derived Growth Factor, Receptors, Vascular Endothelial Growth Factor, Sequence Alignment, Signal Transduction

Directed cell migrations are important for development, but the signaling pathways and mechanisms responsible for guiding cell migration in vivo are poorly understood. Migration of border cells during Drosophila oogenesis is a simple and attractive model system in which to address these questions. We demonstrate that PVR, a receptor tyrosine kinase related to mammalian PDGF and VEGF receptors, acts in border cells to guide them to the oocyte. The oocyte is the source of a ligand for PVR, PDGF/VEGF factor 1 (PVF1). Intriguingly, the guidance function of PVR is largely redundant with that of EGFR. We present evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal.

Alternate JournalCell

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