Skip to Content

Dual roles for patched in sequestering and transducing Hedgehog.

TitleDual roles for patched in sequestering and transducing Hedgehog.
Publication TypeJournal Article
Year of Publication1996
AuthorsChen Y, Struhl G
JournalCell
Volume87
Issue3
Pagination553-63
Date Published1996 Nov 1
ISSN0092-8674
KeywordsAlleles, Animals, Animals, Genetically Modified, Drosophila melanogaster, Drosophila Proteins, Gene Expression Regulation, Developmental, Hedgehog Proteins, Insect Hormones, Insect Proteins, Macromolecular Substances, Membrane Proteins, Models, Biological, Multigene Family, Proteins, Receptors, Cell Surface, Receptors, G-Protein-Coupled, Signal Transduction, Wing
Abstract

Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc-Smo complex, and thereby induces Smo activity. Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement.

Alternate JournalCell


biblio | about seo