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New "hogs" in Hedgehog transport and signal reception.

TitleNew "hogs" in Hedgehog transport and signal reception.
Publication TypeJournal Article
Year of Publication2006
AuthorsWilson CW, Chuang P-T
Date Published2006 May 5
KeywordsAnimals, Embryonic Development, Hedgehog Proteins, Heparan Sulfate Proteoglycans, Humans, Macromolecular Substances, Protein Binding, Protein Transport, Receptors, Cell Surface, Signal Transduction, Trans-Activators

A recent paper in Cell (Yao et al., 2006) and two papers in Developmental Cell (Tenzen et al., 2006; Zhang et al., 2006) identify a new receptor component for Hedgehog, a key morphogen in embryonic development. Many other proteins that bind to Hedgehog in the extracellular matrix or on the cell surface have been identified. In light of these recent discoveries, we discuss how these factors control the stability, transport, reception, and availability of Hedgehog in modulating Hedgehog-mediated responses.

Alternate JournalCell

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