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Multiple roles for notch in Drosophila myogenesis.

TitleMultiple roles for notch in Drosophila myogenesis.
Publication TypeJournal Article
Year of Publication1998
AuthorsFuerstenberg S, Giniger E
JournalDevelopmental biology
Date Published1998 Sep 1
KeywordsAnimals, Animals, Genetically Modified, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Ectoderm, Embryo, Nonmammalian, Embryonic Induction, Enhancer Elements, Genetic, Fungal Proteins, Gene Expression Regulation, Developmental, Membrane Proteins, Mesoderm, Muscles, Receptors, Cell Surface, Receptors, Notch, Saccharomyces cerevisiae Proteins, Signal Transduction, Stem Cells, Transcription Factors

Notch plays a role in many cell fate decisions in the developing Drosophila embryo, often at successive stages during the formation of a single tissue. In the embryonic mesoderm, Notch is involved in the process by which muscle progenitors are selected from a field of equivalent myoblasts. We have investigated the roles of Notch in somatic myogenesis and show that Notch can affect at least two additional steps in muscle development. Subsequent to the initial specification of progenitors, myoblast identity remains sensitive to mesodermal Notch activity until the time of fusion. Additionally, Notch is capable of suppressing muscle development nonautonomously by regulating a signal that emanates from the ectoderm.

Alternate JournalDev. Biol.

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