| Title | The JAK/STAT pathway and Drosophila development. |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Luo H, Dearolf CR |
| Journal | BioEssays : news and reviews in molecular, cellular and developmental biology |
| Volume | 23 |
| Issue | 12 |
| Pagination | 1138-47 |
| Date Published | 2001 Dec |
| ISSN | 0265-9247 |
| Keywords | Animals, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Extremities, Eye, Glycoproteins, Insect Proteins, Janus Kinases, Protein-Tyrosine Kinases, Sex Determination Processes, Signal Transduction, STAT Transcription Factors, Trans-Activators, Transcription Factors, Wing |
| Abstract | The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism to identify other interacting molecules and pathways. Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling. |
| DOI | 10.1002/bies.10016 |
| Alternate Journal | Bioessays |