| Title | The JAK-STAT pathway in Drosophila. |
| Publication Type | Journal Article |
| Year of Publication | 1997 |
| Authors | Hou XS, Perrimon N |
| Journal | Trends in genetics : TIG |
| Volume | 13 |
| Issue | 3 |
| Pagination | 105-10 |
| Date Published | 1997 Mar |
| ISSN | 0168-9525 |
| Keywords | Animals, Cell Division, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Embryo, Nonmammalian, Female, Gene Expression Regulation, Developmental, Janus Kinases, Larva, Milk Proteins, Neoplasms, Protein-Tyrosine Kinases, Signal Transduction, STAT Transcription Factors, STAT5 Transcription Factor, Trans-Activators, Transcription Factors |
| Abstract | Recent studies in Drosophila have identified a single JAK and a single STAT protein. Genetic and biochemical analyses reveal that these two proteins operate in the same signal transduction pathway. Phenotypic analyses of JAK and STAT mutants implicate this pathway in a number of developmental decisions, in particular the regulation of pair-rule genes and fly hematopoiesis. |
| Alternate Journal | Trends Genet. |