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The JAK-STAT pathway in Drosophila.

TitleThe JAK-STAT pathway in Drosophila.
Publication TypeJournal Article
Year of Publication1997
AuthorsHou XS, Perrimon N
JournalTrends in genetics : TIG
Date Published1997 Mar
KeywordsAnimals, Cell Division, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Embryo, Nonmammalian, Female, Gene Expression Regulation, Developmental, Janus Kinases, Larva, Milk Proteins, Neoplasms, Protein-Tyrosine Kinases, Signal Transduction, STAT Transcription Factors, STAT5 Transcription Factor, Trans-Activators, Transcription Factors

Recent studies in Drosophila have identified a single JAK and a single STAT protein. Genetic and biochemical analyses reveal that these two proteins operate in the same signal transduction pathway. Phenotypic analyses of JAK and STAT mutants implicate this pathway in a number of developmental decisions, in particular the regulation of pair-rule genes and fly hematopoiesis.

Alternate JournalTrends Genet.

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